EpisolveGI acts as a medium acting antacid.
Short term supplements and drugs, such as tums and other common antacids, work from a matter of seconds to a matter of minutes.
Long term antacids start acting within an hour and continue on for multiple hours into the day (8-24hr) by reducing acid production. Common prescription drugs for long term relief include proton pump inhibitors (e.g. Nexium , Omeprazole and Protonix) and H2 antagonists (e.g. Pepcid, Raniditine and Cimetidine).
Medium acting antacids act within minutes and continue to act for a few hours. EpsovleGI is medium-acting antacid. It is a SUSPENSION of olive oil and calcium carbonate. It has three physical components: a physical layer of olive oil, a physical layer of calcium carbonate, and a physical layer of both olive oil and calcium carbonate. Each layer has its own timed and biological role. The layer of calcium carbonate is the fast acting component. It reduces the acid load on the esophageal gastric junction. The layer of olive oil floats to the top of the gastric content and even the refluxed content to protect the mucosa by creating a barrier between the mucosa and the stomach acid. The olive oil is hydrophobic (afraid of water) and sticks to the lining of the esophagus (mucosa) preferentially more than the water. Hence, it reduces the injury to and burning of the mucosa by isolating the tissue of the esophagus( mucosa) from the acid. The third layer of calcium carbonate and olive oil is slowly digested, meaning it slowly releases its components over a few hours. Hence, EpisolveGI keeps neutralizing new acid formation while releasing further olive oil to soothes the GE junction .
EpisolveGI, as a supplement, should be taken during the time of day or night when symptoms are known to be at their worst. Therefore, it can be used as preventive measure such as after dinner and prior to sleep in order to alleviate overnight acid reflux and morning acid mouth sensation. It can also be taken at the end of a high protein meal, which is known to worsen GERD. The usual dose is about 2-4 capsules per meal. Additional doses can be taken, but should not exceed 12 capsules per day.
 These theoretical claims are made based on in vitro experiments.